-Adrenoreceptors Reactivate Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication via PKA-Dependent Control of Viral RTA
نویسندگان
چکیده
-Adrenoreceptors Reactivate Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication via PKA-Dependent Control of Viral RTA Margaret Chang, Helen J. Brown, Alicia Collado-Hidalgo, Jesusa M. Arevalo, Zoran Galic, Tonia L. Symensma, Lena Tanaka, Hongyu Deng, Jerome A. Zack, Ren Sun, and Steve W. Cole* Departments of Microbiology, Immunology and Molecular Genetics, Molecular and Medical Pharmacology, and Medicine, David E. Geffen School of Medicine, University of California, Los Angeles, California; Department of Biological Sciences, Mount Saint Mary’s College, Los Angeles, California; and Jonsson Comprehensive Cancer Center, UCLA AIDS Institute, and UCLA Molecular Biology Institute and Norman Cousins Center, University of California, Los Angeles, California
منابع مشابه
beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA.
Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication is mediated by the viral RTA transcription factor, but little is known about the physiological processes controlling its expression or activity. Links between autonomic nervous system activity and AIDS-associated Kaposi's sarcoma led us to examine the potential influence of catecholamine neurotransmitters. Physiolo...
متن کاملCCAAT/Enhancer-Binding Protein- Is Induced during the Early Stages of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Lytic Cycle Reactivation and Together with the KSHV Replication and Transcription Activator (RTA) Cooperatively Stimulates the Viral RTA, MTA, and PAN Promoters
CCAAT/Enhancer-Binding ProteinIs Induced during the Early Stages of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Lytic Cycle Reactivation and Together with the KSHV Replication and Transcription Activator (RTA) Cooperatively Stimulates the Viral RTA, MTA, and PAN Promoters Shizhen Emily Wang, Frederick Y. Wu,† Yanxing Yu, and Gary S. Hayward* Molecular Virology Laboratories, Department of Pha...
متن کاملFine-Tuning of the Kaposi’s Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic pathogen that displays latent and lytic life cycles. In KS lesions, infiltrated immune cells, secreted viral and/or cellular cytokines, and hypoxia orchestrate a chronic pro-lytic microenvironment that can promote KSHV reactivation. However, only a small subset of viruses spontaneously undergoes lytic replication in this pro-ly...
متن کاملThe Molecular Mechanism of Viral Transactivator Rta-mediated Kaposi’s Sarcoma-associated Herpesvirus (kshv) Lytic Replication
................................................................................................i Acknowledgements................................................................................iii Table of contents......................................................................................v List of abbreviations............................................................................
متن کاملReactivation and Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus: An Update
The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of two phases, latent and lytic. The virus establishes latency as a strategy for avoiding host immune surveillance and fusing symbiotically with the host for lifetime persistent infection. However, latency can be disrupted and KSHV is reactivated for entry into the lytic replication. Viral lytic replication is crucial for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005